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排序方式: 共有196条查询结果,搜索用时 15 毫秒
31.
State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices. 相似文献
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This work uses the molecular dynamics approach to study the effects of functionalization of carbon nanotubes (CNTs) on the mechanical properties of Cu64Zr36 metallic glass (MG). Three types of functional groups, carboxylic, vinyl and ester were used. The effect of CNT volume fraction (Vf) and the number of functional groups attached to CNT, on the mechanical properties and thermal conductivity of CNT-MG composites was analysed using Biovia Materials Studio. At lower values of Vf (from 0 to 5%), the per-centage increase in Young's modulus was approximately 66%. As the value of Vf was increased further (from 5 to 12%), the rate of increase in Young's modulus was reduced to 16%. The thermal conductivity was found to increase from 1.52 W/mK at Vf=0%to 5.88 W/mK at Vf=12%, thus giving an increase of approximately 286%. Functionalization of SWCNT reduced the thermal conductivity of the SWCNT-MG composites. 相似文献
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This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete panels. This paper is divided into two parts. The first part consists of numerical modeling of reinforced concrete panel penetrated with a spherical projectile using concrete damage plasticity (CDP) model, while the second part focuses on the comparison of CDP model and Johnson-Holmquist-2 (JH-2) damage model and their ability to describe the behavior of concrete panel under impact loads. The first and second concrete panels have dimensions of 1500 mm × 1500 mm × 150 mm and 675 mm × 675 mm × 200 mm, respectively, and are meshed using 8-node hexahedron solid elements. The impact object used in the first part is a spherical projectile of 150 mm diameter, while in the second part steel projectile of a length of 152 mm is modeled as rigid element. Failure and scabbing characteristics are studied in the first part. In the second part, the com-parison results are presented as damage contours, kinetic energy of projectile and internal energy of the concrete. The results revealed a severe fracture of the panel and high kinetic energy of the projectile using CDP model comparing to the JH-2 model. In addition, the internal energy of concrete using CDP model was found to be less comparing to the JH-2 model. 相似文献
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The mechanical, thermal and ablation properties of carbon phenolic (C-Ph) composites (Type-I) rein-forced with different weight percentages of organo-modified montmorillonite (o-MMT) nanoclay have been studied experimentally. Ball milling was used to disperse different weight (wt) percentages (0, 1,2,4,6 wt.%) of nanoclay into phenolic resin. Viscosity changes to resin due to nanoclay was studied. On the other hand, nanoclay added phenolic matrix composites (Type-II) were prepared to study the dispersion of nanoclay in phenolic matrix by small angle X-ray scattering and thermal stability changes to the matrix by thermogravimetric analyser (TGA). This data was used to understand the mechanical, thermal and ablation properties of Type-I composites. Inter laminar shear strength (ILSS), flexural strength and flexural modulus of Type I composites increased by about 29%, 12%and 7%respectively at 2 wt.% addition of nanoclay beyond which these properties decreased. This was attributed to reduced fiber volume fraction (%Vf) of Type-I composites due to nanoclay addition at such high loadings. Mass ablation rate of Type-I composites was evaluated using oxy acetylene torch test at low heat flux (125 W/cm2) and high heat flux levels (500 W/cm2). Mass ablation rates have increased at both flux levels marginally up to 2 wt.% addition of nanoclay beyond which it has increased significantly. This is in contrast to increased thermal stability observed for Type-I and Type-Ⅱ composites up to 2 wt.%addition of nanoclay. Increased ablation rates due to nanoclay addition was attributed to higher insulation effi-ciency of nanolcay, which accumulates more heat energy in limited area behind the ablation front and self-propagating ablation mechanisms triggered by thermal decomposition of organic part of nanoclay. 相似文献
35.
While there has been significant previous literature on inventory transshipment, most research has focused on the dealers' demand filling decision (when to fill transshipment requests from other dealers), ignoring the requesting decision (when to send transshipment requests to other dealers). In this paper we develop optimal inventory transshipment policies that incorporate both types of decisions. We consider a decentralized system in which the dealers are independent of the manufacturer and of each other. We first study a network consisting of a very large number of dealers. We prove that the optimal inventory and transshipment decisions for an individual dealer are controlled by threshold rationing and requesting levels. Then, in order to study the impact of transshipment among independent dealers in a smaller dealer network, we consider a decentralized two‐dealer network and use a game theoretic approach to characterize the equilibrium inventory strategies of the individual dealers. An extensive numerical study highlights the impact of the requesting decision on the dealers' equilibrium behavior in a decentralized setting. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006 相似文献
36.
Issaka K Souaré 《African Security Review》2013,22(3):96-97
The popular adage has it that ‘prevention is better than cure’. Given the heavy and enduring costs of armed conflicts, there is no disputing the fact that making efforts to prevent them from breaking out in the first place is better than waiting until it is too late. This entails two things: conflict prevention measures and early warning systems. Anything that could be done to effectively address the root causes of a conflict before it turns violent may fit into the former, while the latter aims to identify threats to these elements so that effective conflict prevention measures can be taken. In other words, ensuring ‘human security’ is the thrust of the former, while the latter serves as a surveillance camera for any deficit in providing the different components of this ‘human security’. It is with these two important issues that this essay deals, with particular reference to West Africa. 相似文献
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By running life tests at higher stress levels than normal operating conditions, accelerated life testing (ALT) quickly yields information on the lifetime distribution of a test unit. The lifetime at the design stress is then estimated through extrapolation using a regression model. In constant‐stress testing, a unit is tested at a fixed stress level until failure or the termination time point of test, whereas step‐stress testing allows the experimenter to gradually increase the stress levels at some prefixed time points during the test. In this work, the optimal k‐level constant‐stress and step‐stress ALTs are compared for the exponential failure data under complete sampling and Type‐I censoring. The objective is to quantify the advantage of using the step‐stress testing relative to the constant‐stress one. Assuming a log‐linear life–stress relationship with the cumulative exposure model for the effect of changing stress in step‐stress testing, the optimal design points are determined under C/D/A‐optimality criteria. The efficiency of step‐stress testing to constant‐stress one is then discussed in terms of the ratio of optimal objective functions based on the information matrix. © 2013 Wiley Periodicals, Inc. Naval Research Logistics 00: 000–000, 2013 相似文献
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