| N-乙基间甲氧基苯胺之合成工艺改进 |
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| 引用本文： | 梅林,宋世远,龚海峰,赖容,张科,彭见.N-乙基间甲氧基苯胺之合成工艺改进[J].后勤工程学院学报,2009,25(4):53-55,61. |
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| 作者姓名： | 梅林 宋世远 龚海峰 赖容 张科 彭见 |
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| 作者单位： | 1. 后勤工程学院,军事油料应用与管理工程系,重庆,400016
2. 重庆大学,外国语学院,重庆,400044 |
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| 摘 要： | 采用间氨苯酚为原料,以四氢吡喃(THP)作羟基保护剂,以醋酸酐作酰基保护剂和氨基单取代的专一选择剂,以溴乙烷作烷基化试剂,硫酸二甲酯作甲基化试剂,在原有最优化合成工艺条件下,经六步反应合成N-乙基间甲氧基苯胺,产率达到65.9%.经改进后的合成路线反应步骤虽有所增加,但收率提高了8.3%.
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| 关 键 词： | 合成 间氨苯酚 溴乙烷 硫酸二甲酯 N-乙基间甲氧基苯胺 四氢吡喃 |
Improvement on Synthesis Process Route of N-ethyl-m-methyoxy Aniline |
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| MEI Lin,SONG Shi-yuan,GONG Hai-feng,LAI Rong,ZHANG Ke,PENG Jian.Improvement on Synthesis Process Route of N-ethyl-m-methyoxy Aniline[J].Journal of Logistical Engineering University,2009,25(4):53-55,61. |
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| Authors: | MEI Lin SONG Shi-yuan GONG Hai-feng LAI Rong ZHANG Ke PENG Jian |
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| Institution: | 1.Dept.of Oil Application & Management Engineering;LEU;Chongqing 400016;China;2.College of Foreign Language;Chongqing University;Chongqing 400044;China |
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| Abstract: | Employing the same optimization synthesis process condition before,N-ethyl-m-methyoxy aniline is synthesized by six reaction steps,the yield rate reaches to 65.9%,while m-aminophenol is used as reactant,tetrahydropyran as hydroxyl shielding effect agent,acetic anhydride as acyl protection reactant and amidogen mono-substituted alternative reactant,ethyl bromide as ethyl reactant,dimethylsulfate as methyl reactant.Compared with former improved synthesis process route,although the reaction steps of present sy... |
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| Keywords: | synthesize m-aminophenol ethyl bromide dimethylsulfate N-ethyl-m-methyoxy aniline tetrahydropyran |
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