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41.
We develop a simple algorithm, which does not require convolutions, for computing the distribution of the residual life when the renewal process is discrete. We also analyze the algorithm for the particular case of lattice distributions, and we show how it can apply to an inventory problem. © 1999 John Wiley & Sons, Inc. Naval Research Logistics 46: 435–443, 1999  相似文献   
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State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.  相似文献   
44.
The human visual system is still an important factor in military warfare; military personnel receive training on effective search strategies, and camouflage that can effectively conceal objects and personnel is a key component of a successful integrated survivability strategy. Previous methods of camouflage assessment have, amongst others, used psychophysics to generate distinctiveness metrics. However, the population from which the human observers are drawn is often not well defined, or necessarily appropriate. In this experiment we designed a new platform for testing multiple patterns based on a camouflaged object detection task, and investigate whether trained military observers perform better than civilians. We use a two-alternative forced choice paradigm, with participants searching images of woodland for a replica military helmet displaying Olive Green, Multi Terrain Pattern, US Marine Pattern or, as a conspicuous control, UN Peacekeeper Blue. Our data show that there is no difference in detection performance between the two observer groups but that there are clear differences in the effectiveness of the different helmet colour patterns in a temperate woodland environment. We conclude that when tasks involve very short stimulus presentation times, task-specific training has little effect on the success of target detection and thus this paradigm is particularly suitable for robust estimates of camouflage efficacy.  相似文献   
45.
The Middle East is a crucial region for the global nonproliferation regime. In 2010, the state parties to the Treaty on the Non-Proliferation of Nuclear Weapons proposed a conference on a Middle East Weapons of Mass Destruction-Free Zone. The nuclear weapon-free zone model, on which this idea builds, has achieved important results in other regions, but faces especially stark challenges in the Middle East. However, the attempt to apply the boldly imaginative zone approach to the Middle East holds promise for building a more inclusive dialogue on nonproliferation and regional security.  相似文献   
46.
It is intrinsic to the nature of military competition that the unit acquisition costs of defence systems rise generation by generation. Traditional “bottom‐up” methods of cost‐estimating cannot meet the increasing demands for extensive studies of many options before commencing design and, while “top‐down” estimating techniques are an improvement, in particular by reducing the time required for preparing estimates, they also are inadequate to meet current requirements. A new method has been devised, therefore, further developing “top‐down” methods using Bayesian techniques to make best use of the available information, whether certain or uncertain, and its accuracy established by example.  相似文献   
47.

This paper analyzes a set of observations by the Congressional Budget Office (CBO) on individual weapons systems regarding whether large amounts of excess capacity exist and whether short run average cost (SRAC) appears to be severely decreasing. It is shown that the amount of excess capacity and steepness of SRAC are essentially independent of output rate. It is then argued that this suggests that production is occurring in inefficiently large plants—i.e.—off the long run cost curve.  相似文献   
48.
Abstract

This article answers three questions: What is the nature of the Long War? How is progress (or lack thereof) to be assessed? Where is it likely to go next? An appreciation of Clausewitz shows that practical centers of gravity exist for the Long War, and that the conflict pivots upon the ability to persuasively link ideology to events via a strategic narrative. A close examination of an illustrative case study, the interaction between the US and the late Abu Musab al-Zarqawi in Iraq 2004 – 2006, shows that Al Qaeda has suffered a severe setback, but also that the nature of the war is set to shift yet again. Further tangible progress for the US requires waging the Long War as a global counterinsurgency based on a strategy of ‘selective identification’ (versus pure ‘disaggregation’) as well as an understanding of how to more effectively craft a strategic narrative.  相似文献   
49.
In its colony of Angola, Portugal during its colonial wars (1961–1974) was able to exploit the economic dependence and divided population loyalties of its hostile neighbours the Congo and Zambia as well as the cleavages within the nationalist movements to prevent a crippling insurgency. The rulers of both countries were largely dependent on Angola for trade, and were eager to have the side effects of the robust Angolan economy with its 11% annual growth brush off on their own moribund ones. While relationships were never comfortable, the sponsors of revolution were forced to reign in their ‘freedom fighters’ in order to maintain the functioning of their export-dependent economies. Portuguese leadership also played a vital role, as it was able to bring together diverse elements of national power in a concerted policy for dealing with these enemies, whether they were insurgents or their sanctuary countries. This policy of leveraging national power and playing on the vulnerabilities of its opponents worked well during its war in Angola and still holds valuable lessons for countries that find themselves in similar circumstances.  相似文献   
50.
On 4 January 1961 in Baixa do Cassange, in the north of Angola, the blacks who worked in the cotton fields began a strike. The army with air support was called to quell the rebellion, and the article emphasizes the importance of air support tethered to the ground forces, particularly in a remote and vast area of operations in the tropical rainy season. In this case, the support originally came in the form a squadron of Lockheed PV-2 Harpoons from Luanda, some 300 kilometers away. These open-ocean reconnaissance aircraft and their crews were ill-suited for the task. When this became apparent, four small Auster D5/160s were relocated from Negage to Malange, among the ground forces. The Austers flew reconnaissance missions over the troubled zones, dropped provisions and messages to the advancing ground forces, and served as a backup communications link. When the strike ceased after three weeks, the Austers assumed a humanitarian role in support of the starving population. The conclusion is that air support to ground forces is indispensable, must be properly tailored to the job, and must operate as an integral part of the ground forces.  相似文献   
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