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An area defense consists of several groups that act independently, i.e., do not communicate with each other. Each group has a fixed number of defenders and a controller that allocates these defenders optimally against the individual attackers comprising an attack. We analyze the effectiveness of this partially coordinated defense against a simultaneous attack of known size in which all attackers are considered to be equally lethal. © 2004 Wiley Periodicals, Inc. Naval Research Logistics, 2005.  相似文献   
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State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.  相似文献   
105.
This work uses the molecular dynamics approach to study the effects of functionalization of carbon nanotubes (CNTs) on the mechanical properties of Cu64Zr36 metallic glass (MG). Three types of functional groups, carboxylic, vinyl and ester were used. The effect of CNT volume fraction (Vf) and the number of functional groups attached to CNT, on the mechanical properties and thermal conductivity of CNT-MG composites was analysed using Biovia Materials Studio. At lower values of Vf (from 0 to 5%), the per-centage increase in Young's modulus was approximately 66%. As the value of Vf was increased further (from 5 to 12%), the rate of increase in Young's modulus was reduced to 16%. The thermal conductivity was found to increase from 1.52 W/mK at Vf=0%to 5.88 W/mK at Vf=12%, thus giving an increase of approximately 286%. Functionalization of SWCNT reduced the thermal conductivity of the SWCNT-MG composites.  相似文献   
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This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete panels. This paper is divided into two parts. The first part consists of numerical modeling of reinforced concrete panel penetrated with a spherical projectile using concrete damage plasticity (CDP) model, while the second part focuses on the comparison of CDP model and Johnson-Holmquist-2 (JH-2) damage model and their ability to describe the behavior of concrete panel under impact loads. The first and second concrete panels have dimensions of 1500 mm × 1500 mm × 150 mm and 675 mm × 675 mm × 200 mm, respectively, and are meshed using 8-node hexahedron solid elements. The impact object used in the first part is a spherical projectile of 150 mm diameter, while in the second part steel projectile of a length of 152 mm is modeled as rigid element. Failure and scabbing characteristics are studied in the first part. In the second part, the com-parison results are presented as damage contours, kinetic energy of projectile and internal energy of the concrete. The results revealed a severe fracture of the panel and high kinetic energy of the projectile using CDP model comparing to the JH-2 model. In addition, the internal energy of concrete using CDP model was found to be less comparing to the JH-2 model.  相似文献   
107.
The mechanical, thermal and ablation properties of carbon phenolic (C-Ph) composites (Type-I) rein-forced with different weight percentages of organo-modified montmorillonite (o-MMT) nanoclay have been studied experimentally. Ball milling was used to disperse different weight (wt) percentages (0, 1,2,4,6 wt.%) of nanoclay into phenolic resin. Viscosity changes to resin due to nanoclay was studied. On the other hand, nanoclay added phenolic matrix composites (Type-II) were prepared to study the dispersion of nanoclay in phenolic matrix by small angle X-ray scattering and thermal stability changes to the matrix by thermogravimetric analyser (TGA). This data was used to understand the mechanical, thermal and ablation properties of Type-I composites. Inter laminar shear strength (ILSS), flexural strength and flexural modulus of Type I composites increased by about 29%, 12%and 7%respectively at 2 wt.% addition of nanoclay beyond which these properties decreased. This was attributed to reduced fiber volume fraction (%Vf) of Type-I composites due to nanoclay addition at such high loadings. Mass ablation rate of Type-I composites was evaluated using oxy acetylene torch test at low heat flux (125 W/cm2) and high heat flux levels (500 W/cm2). Mass ablation rates have increased at both flux levels marginally up to 2 wt.% addition of nanoclay beyond which it has increased significantly. This is in contrast to increased thermal stability observed for Type-I and Type-Ⅱ composites up to 2 wt.%addition of nanoclay. Increased ablation rates due to nanoclay addition was attributed to higher insulation effi-ciency of nanolcay, which accumulates more heat energy in limited area behind the ablation front and self-propagating ablation mechanisms triggered by thermal decomposition of organic part of nanoclay.  相似文献   
108.
Cyber operations are relatively a new phenomenon of the last two decades.During that period,they have increased in number,complexity,and agility,while their design and development have been processes well kept under secrecy.As a consequence,limited data(sets)regarding these incidents are available.Although various academic and practitioner public communities addressed some of the key points and dilemmas that surround cyber operations(such as attack,target identification and selection,and collateral damage),still methodologies and models are needed in order to plan,execute,and assess them in a responsibly and legally compliant way.Based on these facts,it is the aim of this article to propose a model that i))estimates and classifies the effects of cyber operations,and ii)assesses proportionality in order to support targeting decisions in cyber operations.In order to do that,a multi-layered fuzzy model was designed and implemented by analysing real and virtual realistic cyber operations combined with interviews and focus groups with technical-military experts.The proposed model was evaluated on two cyber operations use cases in a focus group with four technical-military experts.Both the design and the results of the evaluation are revealed in this article.  相似文献   
109.
While there has been significant previous literature on inventory transshipment, most research has focused on the dealers' demand filling decision (when to fill transshipment requests from other dealers), ignoring the requesting decision (when to send transshipment requests to other dealers). In this paper we develop optimal inventory transshipment policies that incorporate both types of decisions. We consider a decentralized system in which the dealers are independent of the manufacturer and of each other. We first study a network consisting of a very large number of dealers. We prove that the optimal inventory and transshipment decisions for an individual dealer are controlled by threshold rationing and requesting levels. Then, in order to study the impact of transshipment among independent dealers in a smaller dealer network, we consider a decentralized two‐dealer network and use a game theoretic approach to characterize the equilibrium inventory strategies of the individual dealers. An extensive numerical study highlights the impact of the requesting decision on the dealers' equilibrium behavior in a decentralized setting. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006  相似文献   
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