Equity in genetic newborn screening

State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.     

Using stochastic programming to solve an outpatient appointment scheduling problem with random service and arrival times

We study a stochastic outpatient appointment scheduling problem (SOASP) in which we need to design a schedule and an adaptive rescheduling (i.e., resequencing or declining) policy for a set of patients. Each patient has a known type and associated probability distributions of random service duration and random arrival time. Finding a provably optimal solution to this problem requires solving a multistage stochastic mixed‐integer program (MSMIP) with a schedule optimization problem solved at each stage, determining the optimal rescheduling policy over the various random service durations and arrival times. In recognition that this MSMIP is intractable, we first consider a two‐stage model (TSM) that relaxes the nonanticipativity constraints of MSMIP and so yields a lower bound. Second, we derive a set of valid inequalities to strengthen and improve the solvability of the TSM formulation. Third, we obtain an upper bound for the MSMIP by solving the TSM under the feasible (and easily implementable) appointment order (AO) policy, which requires that patients are served in the order of their scheduled appointments, independent of their actual arrival times. Fourth, we propose a Monte Carlo approach to evaluate the relative gap between the MSMIP upper and lower bounds. Finally, in a series of numerical experiments, we show that these two bounds are very close in a wide range of SOASP instances, demonstrating the near‐optimality of the AO policy. We also identify parameter settings that result in a large gap in between these two bounds. Accordingly, we propose an alternative policy based on neighbor‐swapping. We demonstrate that this alternative policy leads to a much tighter upper bound and significantly shrinks the gap.     

Mechanical properties and thermal conductivity of pristine andfunctionalized carbon nanotube reinforced metallic glass composites:A molecular dynamics approach

This work uses the molecular dynamics approach to study the effects of functionalization of carbon nanotubes (CNTs) on the mechanical properties of Cu64Zr36 metallic glass (MG). Three types of functional groups, carboxylic, vinyl and ester were used. The effect of CNT volume fraction (Vf) and the number of functional groups attached to CNT, on the mechanical properties and thermal conductivity of CNT-MG composites was analysed using Biovia Materials Studio. At lower values of Vf (from 0 to 5％), the per-centage increase in Young's modulus was approximately 66％. As the value of Vf was increased further (from 5 to 12％), the rate of increase in Young's modulus was reduced to 16％. The thermal conductivity was found to increase from 1.52 W/mK at Vf=0％to 5.88 W/mK at Vf=12％, thus giving an increase of approximately 286％. Functionalization of SWCNT reduced the thermal conductivity of the SWCNT-MG composites.     

Damage modeling of ballistic penetration and impact behavior of concrete panel under low and high velocities

This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete panels. This paper is divided into two parts. The first part consists of numerical modeling of reinforced concrete panel penetrated with a spherical projectile using concrete damage plasticity (CDP) model, while the second part focuses on the comparison of CDP model and Johnson-Holmquist-2 (JH-2) damage model and their ability to describe the behavior of concrete panel under impact loads. The first and second concrete panels have dimensions of 1500 mm × 1500 mm × 150 mm and 675 mm × 675 mm × 200 mm, respectively, and are meshed using 8-node hexahedron solid elements. The impact object used in the first part is a spherical projectile of 150 mm diameter, while in the second part steel projectile of a length of 152 mm is modeled as rigid element. Failure and scabbing characteristics are studied in the first part. In the second part, the com-parison results are presented as damage contours, kinetic energy of projectile and internal energy of the concrete. The results revealed a severe fracture of the panel and high kinetic energy of the projectile using CDP model comparing to the JH-2 model. In addition, the internal energy of concrete using CDP model was found to be less comparing to the JH-2 model.     

Damage mechanics and energy absorption capabilities of naturalfiber reinforced elastomeric based bio composite for sacrificial structural applications

The present study deals with the experimental, finite element (FE) and analytical assessment of low ballistic impact response of proposedflexible'green' composite make use of naturally available jute and rubber as the constituents of the composite with stacking sequences namely jute/rubber/jute (JRJ), jute/rubber/rubber/jute (JRRJ) and jute/rubber/jute/rubber/jute (JRJRJ). Ballistic impact tests were carried out by firing a conical projectile using a gas gun apparatus at lower range of ballistic impact regime. The ballistic impact response of the proposed flexible composites are assesses based on energy absorption and damage mechanism. Results revealed that inclusion of natural rubber aids in better energy ab-sorption and mitigating the failure of the proposed composite. Among the three different stacking se-quences of flexible composites considered, JRJRJ provides better ballistic performance compared to its counterparts. The damage study reveals that the main mechanism of failure involved in flexible com-posites is matrix tearing as opposed to matrix cracking in stiff composites indicating that the proposedflexible composites are free from catastrophic failure. Results obtained from experimental, FE and analytical approach pertaining to energy absorption and damage mechanism agree well with each other. The proposed flexible composites due to their exhibited energy absorption capabilities and damage mechanism are best suited as claddings for structural application subjected to impact with an aim of protecting the main structural component from being failed catastrophically.     

Real-time prediction of projectile penetration to laminates by training machine learning models withfinite element solver as the trainer

Studies on ballistic penetration to laminates is complicated, but important for design effective protection of structures. Experimental means of study is expensive and can often be dangerous. Numerical simu-lation has been an excellent supplement, but the computation is time-consuming. Main aim of this thesis was to develop and test an effective tool for real-time prediction of projectile penetrations to laminates by training a neural network and a decision tree regression model. A large number of finite element models were developed;the residual velocities of projectiles fromfinite element simulations were used as the target data and processed to produce sufficient number of training samples. Study focused on steel 4340tpolyurea laminates with various configurations. Four different 3D shapes of the projectiles were modeled and used in the training. The trained neural network and decision tree model was tested using independently generated test samples using finite element models. The predicted projectile velocity values using the trained machine learning models are then compared with thefinite element simulation to verify the effectiveness of the models. Additionally, both models were trained using a published experimental data of projectile impacts to predict residual velocity of projectiles for the unseen samples. Performance of both the models was evaluated and compared. Models trained with Finite element simulation data samples were found capable to give more accurate predication, compared to the models trained with experimental data, becausefinite element modeling can generate much larger training set, and thus finite element solvers can serve as an excellent teacher. This study also showed that neural network model performs better with small experimental dataset compared to decision tree regression model.     

Effect of organo-modified montmorillonite nanoclay on mechanical,thermal and ablation behavior of carbon fiber/phenolic resin composites

The mechanical, thermal and ablation properties of carbon phenolic (C-Ph) composites (Type-I) rein-forced with different weight percentages of organo-modified montmorillonite (o-MMT) nanoclay have been studied experimentally. Ball milling was used to disperse different weight (wt) percentages (0, 1,2,4,6 wt.％) of nanoclay into phenolic resin. Viscosity changes to resin due to nanoclay was studied. On the other hand, nanoclay added phenolic matrix composites (Type-II) were prepared to study the dispersion of nanoclay in phenolic matrix by small angle X-ray scattering and thermal stability changes to the matrix by thermogravimetric analyser (TGA). This data was used to understand the mechanical, thermal and ablation properties of Type-I composites. Inter laminar shear strength (ILSS), flexural strength and flexural modulus of Type I composites increased by about 29％, 12％and 7％respectively at 2 wt.％ addition of nanoclay beyond which these properties decreased. This was attributed to reduced fiber volume fraction (％Vf) of Type-I composites due to nanoclay addition at such high loadings. Mass ablation rate of Type-I composites was evaluated using oxy acetylene torch test at low heat flux (125 W/cm2) and high heat flux levels (500 W/cm2). Mass ablation rates have increased at both flux levels marginally up to 2 wt.％ addition of nanoclay beyond which it has increased significantly. This is in contrast to increased thermal stability observed for Type-I and Type-Ⅱ composites up to 2 wt.％addition of nanoclay. Increased ablation rates due to nanoclay addition was attributed to higher insulation effi-ciency of nanolcay, which accumulates more heat energy in limited area behind the ablation front and self-propagating ablation mechanisms triggered by thermal decomposition of organic part of nanoclay.     

A higher order coupled frequency characteristics study of smartmagneto-electro-elastic composite plates with cut-outs using finite element methods

This article deals with investigating the effect of cut-outs on the natural frequencies of magneto-electro-elastic (MEE) plates incorporating finite element methods based on higher order shear deformation theory (HSDT). In order to consider the influence of cut-out, the energy of the cut-out domain is sub-tracted from the total energy of the entire plate. The governing equations of motions are derived through incorporating Hamilton's principle and the solution is obtained using condensation technique. The proposed numerical formulation is verified with the results of previously published literature as well as the numerical software. In addition, this research focuses on evaluating the effect of geometrical skewness and boundary conditions on the frequency response. The influence of cut-outs on the degree of coupling between magnetic, electric and elasticfields is also investigated.