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451.
H. W. Kuhn 《海军后勤学研究》2005,52(1):7-21
This paper has been presented with the Best Paper Award. It will appear in print in Volume 52, No. 1, February 2005. 相似文献
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This article considers batch scheduling with centralized and decentralized decisions. The context of our study is concurrent open shop scheduling where the jobs are to be processed on a set of independent dedicated machines, which process designated operations of the jobs in batches. The batching policy across the machines can be centralized or decentralized. We study such scheduling problems with the objectives of minimizing the maximum lateness, weighted number of tardy jobs, and total weighted completion time, when the job sequence is determined in advance. We present polynomial time dynamic programming algorithms for some cases of these problems and pseudo‐polynomial time algorithms for some problems that are NP‐hard in the ordinary sense. © 2010 Wiley Periodicals, Inc. Naval Research Logistics 58: 17–27, 2011 相似文献
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State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices. 相似文献
458.
We study a stochastic outpatient appointment scheduling problem (SOASP) in which we need to design a schedule and an adaptive rescheduling (i.e., resequencing or declining) policy for a set of patients. Each patient has a known type and associated probability distributions of random service duration and random arrival time. Finding a provably optimal solution to this problem requires solving a multistage stochastic mixed‐integer program (MSMIP) with a schedule optimization problem solved at each stage, determining the optimal rescheduling policy over the various random service durations and arrival times. In recognition that this MSMIP is intractable, we first consider a two‐stage model (TSM) that relaxes the nonanticipativity constraints of MSMIP and so yields a lower bound. Second, we derive a set of valid inequalities to strengthen and improve the solvability of the TSM formulation. Third, we obtain an upper bound for the MSMIP by solving the TSM under the feasible (and easily implementable) appointment order (AO) policy, which requires that patients are served in the order of their scheduled appointments, independent of their actual arrival times. Fourth, we propose a Monte Carlo approach to evaluate the relative gap between the MSMIP upper and lower bounds. Finally, in a series of numerical experiments, we show that these two bounds are very close in a wide range of SOASP instances, demonstrating the near‐optimality of the AO policy. We also identify parameter settings that result in a large gap in between these two bounds. Accordingly, we propose an alternative policy based on neighbor‐swapping. We demonstrate that this alternative policy leads to a much tighter upper bound and significantly shrinks the gap. 相似文献
459.
This work uses the molecular dynamics approach to study the effects of functionalization of carbon nanotubes (CNTs) on the mechanical properties of Cu64Zr36 metallic glass (MG). Three types of functional groups, carboxylic, vinyl and ester were used. The effect of CNT volume fraction (Vf) and the number of functional groups attached to CNT, on the mechanical properties and thermal conductivity of CNT-MG composites was analysed using Biovia Materials Studio. At lower values of Vf (from 0 to 5%), the per-centage increase in Young's modulus was approximately 66%. As the value of Vf was increased further (from 5 to 12%), the rate of increase in Young's modulus was reduced to 16%. The thermal conductivity was found to increase from 1.52 W/mK at Vf=0%to 5.88 W/mK at Vf=12%, thus giving an increase of approximately 286%. Functionalization of SWCNT reduced the thermal conductivity of the SWCNT-MG composites. 相似文献
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This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete panels. This paper is divided into two parts. The first part consists of numerical modeling of reinforced concrete panel penetrated with a spherical projectile using concrete damage plasticity (CDP) model, while the second part focuses on the comparison of CDP model and Johnson-Holmquist-2 (JH-2) damage model and their ability to describe the behavior of concrete panel under impact loads. The first and second concrete panels have dimensions of 1500 mm × 1500 mm × 150 mm and 675 mm × 675 mm × 200 mm, respectively, and are meshed using 8-node hexahedron solid elements. The impact object used in the first part is a spherical projectile of 150 mm diameter, while in the second part steel projectile of a length of 152 mm is modeled as rigid element. Failure and scabbing characteristics are studied in the first part. In the second part, the com-parison results are presented as damage contours, kinetic energy of projectile and internal energy of the concrete. The results revealed a severe fracture of the panel and high kinetic energy of the projectile using CDP model comparing to the JH-2 model. In addition, the internal energy of concrete using CDP model was found to be less comparing to the JH-2 model. 相似文献