Predicting older-donor kidneys' post-transplant renal function using pre-transplant data

This paper provides a methodology for predicting post-transplant kidney function, that is, the 1-year post-transplant estimated Glomerular Filtration Rate (eGFR-1) for each donor-candidate pair. We apply customized machine-learning algorithms to pre-transplant donor and recipient data to determine the probability of achieving an eGFR-1 of at least 30 ml/min. This threshold was chosen because there is insufficient survival benefit if the kidney fails to generate an eGFR-1 ≥ 30 ml/min. For some donor-candidate pairs, the developed algorithm provides highly accurate predictions. For others, limitations of previous transplants' data results in noisier predictions. However, because the same kidney is offered to many candidates, we identify those pairs for whom the predictions are highly accurate. Out of 6977 discarded older-donor kidneys that were a match with at least one transplanted kidney, 5282 had one or more identified candidate, who were offered that kidney, did not accept any other offer, and would have had ≥80% chance of achieving eGFR-1 ≥ 30 ml/min, had the kidney been transplanted. We also show that transplants with ≥80% chance of achieving eGFR-1 ≥ 30 ml/min and that survive 1 year have higher 10-year death-censored graft survival probabilities than all older-donor transplants that survive 1 year (73.61% vs. 70.48%, respectively).     

The nexus between military expenditures and economic growth in the BRICS and the US: an empirical note

This empirical note re-examines the causal linkages between military expenditures and economic growth for the BRICS countries (Brazil, Russia, India, China, and South Africa) and that for the USA during the period 1988–2012. Results of Granger causality tests show that military expenditures influence economic growth in the USA, economic growth influences military expenditures in both Brazil and India, a feedback between military expenditures and economic growth in Russia, and no causal relation exists between military expenditures and economic growth in China and South Africa. The findings of this study can provide important policy implications for the BRICS countries and also for the USA.     

Optimal flowshop schedules with no intermediate storage space

In this paper the problem of finding an optimal schedule for the n-job, M-machine flowshop scheduling problem is considered when there is no intermediate space to hold partially completed jobs and the objective function is to minimize the weighted sum of idle times on all machines. By assuming that jobs are processed as early as possible, the problem is modeled as a traveling salesman problem and solved by known solution techniques for the traveling salesman problem. A sample problem is solved and a special case, one involving only two machines, is discussed.     

Optimal state-dependent pricing policies for a class of stochastic multiunit service systems

This paper models a k-unit service system (e.g., a repair, maintenance, or rental facility) with Poisson arrivals, exponential service times, and no queue. If we denote the number of units that are busy as the state of the system, the state-dependent pricing model formalizes the intuitive notion that when most units are idle, the price (i.e., the service charge per unit time) should be low, and when most units are busy, the price should be higher than the average. A computationally efficient algorithm based on a nonlinear programming formulation of the problem is provided for determination of the optimal state-dependent prices. The procedure ultimately reduces to the search on a single variable in an interval to determine the unique intersection point of a concave increasing function and a linear decreasing function. The algorithm takes, on the average, only about 1/2 second per problem on the IBM 360/65 (FORTRAN G Compiler). A discrete optimal-control approach to the problem is shown to result in essentially the same procedure as the nonlinear-programming formulation. Several properties of the optimal state-dependent prices are given. Comparisons of the optimal values of the objective function for the state-dependent and state-independent pricing policies show that the former is on the average, only about 0.7% better than the latter, which may explain partly why state-dependent pricing is not prevalent in many service systems. Potential generalizations of the model are discussed.     

A critical look at the U.S. deceased‐donor organ procurement and utilization system

The U.S. system for procuring and utilizing deceased‐donor organs for transplantation has been studied and written about in many articles. The purpose of this paper is to examine the interactions between the elements that comprise this system, and point out improvement opportunities that may be affected through operations research/management techniques. The authors demonstrate the need for developing data‐driven and analytic tools. In fact, data is used to generate hypotheses and support claims throughout the paper. The paper also points out the need to fully leverage data that is available to researchers, and to seek data that is currently not deposited in a centralized archive.     

Worldwide military spending, 1990–95

The decline in military spending that began in the mid‐1980s continued through 1995, and this decline was widespread both geographically and by level of development. Cuts in military spending appear to have potentially important implications for non‐military spending and fiscal adjustment. In contrast to findings for previous periods, military spending has declined more than proportionately in those countries that have reduced total spending. Countries with Fund programs have reduced military spending more sharply than other developing countries, largely reflecting outcomes in the transition economies. Further, military spending appears to have been less resilient in program countries than other developing countries.