Heart analytics: Analytical modeling of cardiovascular care

Cardiovascular diseases (CVDs) are the leading cause of death and disability both in the United States and worldwide. Despite high morbidity, mortality, and cost in the United States and global healthcare systems, cardiovascular care has been understudied in the healthcare operations management literature. In this paper, we identify research opportunities for healthcare operations management scholars to aid in improving cardiovascular care. We focus on three burdensome conditions, including (1) coronary artery disease, (2) stroke, and (3) heart failure, which, collectively, lead to the vast majority of CVD‐caused mortality and disability. For each condition, we characterize a typical patient's journey in receiving cardiovascular care, elucidating key challenges in improving care and outlining research questions for healthcare operations management scholars. We close with a reference to new research opportunities that emerge as artificial intelligence is likely to transform much of cardiovascular care.     

The impact of manufacturer rebates on supply chain profits

Manufacturer rebates are commonly used as price discount tools for attracting end customers. In this study, we consider a two‐stage supply chain with a manufacturer and a retailer, where a single seasonal product faces uncertain and price‐sensitive demand. We characterize the impact of a manufacturer rebate on the expected profits of both the manufacturer and the retailer. We show that unless all of the customers claim the rebate, the rebate always benefits the manufacturer. Our results thus imply that “mail‐in rebates,” where some customers end up not claiming the rebate, particularly when the size of the rebate is relatively small, always benefit the manufacturer. On the other hand, an “instant rebate,” such as the one offered in the automotive industry where every customer redeems the rebate on the spot when he/she purchases a car, does not necessarily benefit the manufacturer. © 2007 Wiley Periodicals, Inc. Naval Research Logistics, 2007     

A supply chain design model with unreliable supply

Uncertainties abound within a supply chain and have big impacts on its performance. We propose an integrated model for a three‐tiered supply chain network with one supplier, one or more facilities and retailers. This model takes into consideration the unreliable aspects of a supply chain. The properties of the optimal solution to the model are analyzed to reveal the impacts of supply uncertainty on supply chain design decisions. We also propose a general solution algorithm for this model. Computational experience is presented and discussed. © 2007 Wiley Periodicals, Inc. Naval Research Logistics, 2007     

Production and transport logistics scheduling with two transport mode choices

This paper considers a new class of scheduling problems arising in logistics systems in which two different transportation modes are available at the stage of product delivery. The mode with the shorter transportation time charges a higher cost. Each job ordered by the customer is first processed in the manufacturing facility and then transported to the customer. There is a due date for each job to arrive to the customer. Our approach integrates the machine scheduling problem in the manufacturing stage with the transportation mode selection problem in the delivery stage to achieve the global maximum benefit. In addition to studying the NP‐hard special case in which no tardy job is allowed, we consider in detail the problem when minimizing the sum of the total transportation cost and the total weighted tardiness cost is the objective. We provide a branch and bound algorithm with two different lower bounds. The effectiveness of the two lower bounds is discussed and compared. We also provide a mathematical model that is solvable by CPLEX. Computational results show that our branch and bound algorithm is more efficient than CPLEX. © 2005 Wiley Periodicals, Inc. Naval Research Logistics, 2005     

An economic lot‐sizing problem with perishable inventory and economies of scale costs: Approximation solutions and worst case analysis

The costs of many economic activities such as production, purchasing, distribution, and inventory exhibit economies of scale under which the average unit cost decreases as the total volume of the activity increases. In this paper, we consider an economic lot‐sizing problem with general economies of scale cost functions. Our model is applicable to both nonperishable and perishable products. For perishable products, the deterioration rate and inventory carrying cost in each period depend on the age of the inventory. Realizing that the problem is NP‐hard, we analyze the effectiveness of easily implementable policies. We show that the cost of the best Consecutive‐Cover‐Ordering (CCO) policy, which can be found in polynomial time, is guaranteed to be no more than (4 + 5)/7 ≈ 1.52 times the optimal cost. In addition, if the ordering cost function does not change from period to period, the cost of the best CCO policy is no more than 1.5 times the optimal cost. © 2005 Wiley Periodicals, Inc. Naval Research Logistics, 2005.     

Bounds for strength-stress interference via mathematical programming

Problems of bounding Pr {X > Y}, when the distribution of X is subject to certain moment conditions and the distribution of Y is known to be of convexconcave type, are treated in the framework of mathematical programming. Juxtaposed are two programming methods; one is based on the notion of weak duality and the other on the geometry of a certain moment space.     

Comparison of rank aggregation methods based on inherent ability

Ranking is a common task for selecting and evaluating alternatives. In the past few decades, combining rankings results from various sources into a consensus ranking has become an increasingly active research topic. In this study, we focus on the evaluation of rank aggregation methods. We first develop an experimental data generation method, which can provide ground truth ranking for alternatives based on their “inherent ability.” This experimental data generation method can generate the required individual synthetic rankings with adjustable accuracy and length. We propose characterizing the effectiveness of rank aggregation methods by calculating the Kendall tau distance between the aggregated ranking and the ground truth ranking. We then compare four classical rank aggregation methods and present some useful findings on the relative performances of the four methods. The results reveal that both the accuracy and length of individual rankings have a remarkable effect on the comparison results between rank aggregation methods. Our methods and results may be helpful to both researchers and decision‐makers.     

Warehouse sizing to minimize inventory and storage costs

This paper considers a warehouse sizing problem whose objective is to minimize the total cost of ordering, holding, and warehousing of inventory. Unlike typical economic lot sizing models, the warehousing cost structure examined here is not the simple unit rate type, but rather a more realistic step function of the warehouse space to be acquired. In the cases when only one type of stock‐keeping unit (SKU) is warehoused, or when multiple SKUs are warehoused, but, with separable inventory costs, closed form solutions are obtained for the optimal warehouse size. For the case of multi‐SKUs with joint inventory replenishment cost, a heuristic with a provable performance bound of 94% is provided. © 2001 John Wiley & Sons, Inc. Naval Research Logistics 48: 299–312, 2001     

Probabilistic partial set covering problems

In this article, we consider a situation in which a group of facilities need to be constructed in order to serve a given set of customers. However, the facilities cannot guarantee an absolute coverage to any of the customers. Hence, we formulate this problem as one of maximizing the total service reliability of the system subject to a budgetary constraint. For this problem, we develop and test suitable branch-and-bound algorithms and study the effect of problem parameters on solution difficulty. Some generalizations of this problem are also mentioned as possible extensions.