A standardized scan statistic for detecting spatial clusters with estimated parameters

The scan statistic based on likelihood ratios (LRs) have been widely discussed for detecting spatial clusters. When developing the scan statistic, it uses the maximum likelihood estimates of the incidence rates inside and outside candidate clusters to substitute the true values in the LR statistic. However, the parameter estimation has a significant impact on the sensitivity of the scan statistic, which favors the detection of clusters in areas with large population sizes. By presenting the effects of parameter estimation on Kulldorff's scan statistic, we suggest a standardized scan statistic for spatial cluster detection. Compared to the traditional scan statistic, the standardized scan statistic can account for the varying mean and variance of the LR statistic due to inhomogeneous background population sizes. Extensive simulations have been performed to compare the power of the two cluster detection methods with known or/and estimated parameters. The simulation results show that the standardization can help alleviate the effects of parameter estimation and improve the detection of localized clusters. © 2012 Wiley Periodicals, Inc. Naval Research Logistics, 2012     

Irreducibility of joint inventory positions in an assemble‐to‐order system under (r,nQ) policies

In a typical assemble‐to‐order system, a customer order may request multiple items, and the order may not be filled if any of the requested items are out of stock. A key customer service measure when unfilled orders are backordered is the order‐based backorder level. To evaluate this crucial performance measure, a fundamental question is whether the stationary joint inventory positions follow an independent and uniform distribution. In this context, this is equivalent to the irreducibility of the Markov chain formed by the joint inventory positions. This article presents a necessary and sufficient condition for the irreducibility of such a Markov chain through a set of simultaneous Diophantine equations. This result also leads to sufficient conditions that are more general than those in the published reports. © 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011