Layers of Experiments with Adaptive Combined Design

In the field of nanofabrication, engineers often face unique challenges in resource‐limited experimental budgets, the sensitive nature of process behavior with respect to controllable variables, and highly demanding tolerance requirements. To effectively overcome these challenges, this article proposes a methodology for a sequential design of experiments through batches of experimental runs, aptly named Layers of Experiments with Adaptive Combined Design (LoE/ACD). In higher layers, where process behavior is less understood, experimental regions cover more design space and data points are more spread out. In lower layers, experimental regions are more focused to improve understanding of process sensitivities in a local, data‐rich environment. The experimental design is a combination of a space‐filling and an optimal design with a tuning parameter that is dependent on the amount of information accumulated over the various layers. The proposed LoE/ACD method is applied to optimize a carbon dioxide (epet‐CO2) assisted deposition process for fabricating silver nanoparticles with pressure and temperature variables. © 2015 Wiley Periodicals, Inc. Naval Research Logistics 62: 127–142, 2015     

An adaptive forecasting algorithm and inventory policy for products with short life cycles

Products with short life cycles are becoming increasingly common in many industries, such as the personal computer (PC) and mobile phone industries. Traditional forecasting methods and inventory policies can be inappropriate for forecasting demand and managing inventory for a product with a short life cycle because they usually do not take into account the characteristics of the product life cycle. This can result in inaccurate forecasts, high inventory cost, and low service levels. Besides, many forecasting methods require a significant demand history, which is available only after the product has been sold for some time. In this paper, we present an adaptive forecasting algorithm with two characteristics. First, it uses structural knowledge on the product life cycle to model the demand. Second, it combines knowledge on the demand that is available prior to the launch of the product with actual demand data that become available after the introduction of the product to generate and update demand forecasts. Based on the forecasting algorithm, we develop an optimal inventory policy. Since the optimal inventory policy is computationally expensive, we propose three heuristics and show in a numerical study that one of the heuristics generates near‐optimal solutions. The evaluation of our approach is based on demand data from a leading PC manufacturer in the United States, where the forecasting algorithm has been implemented. © 2004 Wiley Periodicals, Inc. Naval Research Logistics, 2004.     

Strategies for managing the flexible capacity in the airline industry

The ability to effectively match supply and demand under uncertainty can result in significant revenue benefits in the airline industry. We study the benefits of a Demand Driven Swapping (DDS) approach that takes advantage of the flexibilities in the system and dynamically swaps aircraft as departures near and more accurate demand information is obtained. We analyze the effectiveness of different DDS strategies, characterized by their frequency (how often the swapping decision is revised), in hedging against demand uncertainty. Swapping aircraft several weeks prior to departures will not cause much disturbance to revenue management and operations, but will be based on highly uncertain demands. On the other hand, revising the swapping decision later will decrease the possibility of bad swaps, but at a higher cost of disrupting airport services and operations. Our objective is to provide guidelines on how the flexible (swappable) capacity should be managed in the system. We study analytical models to gain insights into the critical parameters that affect the revenue benefits of the different swapping strategies. Our study determines the conditions under which each of the different DDS strategies is effective. We complement our analysis by testing the proposed DDS strategies on a set of flight legs, using data obtained from United Airlines. © 2004 Wiley Periodicals, Inc. Naval Research Logistics, 2004.     

Optimal outbound dispatch policies: Modeling inventory and cargo capacity

In this paper, we present an optimization model for coordinating inventory and transportation decisions at an outbound distribution warehouse that serves a group of customers located in a given market area. For the practical problems which motivated this paper, the warehouse is operated by a third party logistics provider. However, the models developed here may be applicable in a more general context where outbound distribution is managed by another supply chain member, e.g., a manufacturer. We consider the case where the aggregate demand of the market area is constant and known per period (e.g., per day). Under an immediate delivery policy, an outbound shipment is released each time a demand is realized (e.g., on a daily basis). On the other hand, if these shipments are consolidated over time, then larger (hence more economical) outbound freight quantities can be dispatched. In this case, the physical inventory requirements at the third party warehouse (TPW) are determined by the consolidated freight quantities. Thus, stock replenishment and outbound shipment release policies should be coordinated. By optimizing inventory and freight consolidation decisions simultaneously, we compute the parameters of an integrated inventory/outbound transportation policy. These parameters determine: (i) how often to dispatch a truck so that transportation scale economies are realized and timely delivery requirements are met, and (ii) how often, and in what quantities, the stock should be replenished at the TPW. We prove that the optimal shipment release timing policy is nonstationary, and we present algorithms for computing the policy parameters for both the uncapacitated and finite cargo capacity problems. The model presented in this study is considerably different from the existing inventory/transportation models in the literature. The classical inventory literature assumes that demands should be satisfied as they arrive so that outbound shipment costs are sunk costs, or else these costs are covered by the customer. Hence, the classical literature does not model outbound transportation costs. However, if a freight consolidation policy is in place then the outbound transportation costs can no longer be ignored in optimization. Relying on this observation, this paper models outbound transportation costs, freight consolidation decisions, and cargo capacity constraints explicitly. © 2002 Wiley Periodicals, Inc. Naval Research Logistics 49: 531–556, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/nav.10030     

The effects of model parameter deviations on the variance of a linearly filtered time series

We consider a general linear filtering operation on an autoregressive moving average (ARMA) time series. The variance of the filter output, which is an important quantity in many applications, is not known with certainty because it depends on the true ARMA parameters. We derive an expression for the sensitivity (i.e., the partial derivative) of the output variance with respect to deviations in the model parameters. The results provide insight into the robustness of many common statistical methods that are based on linear filtering and also yield approximate confidence intervals for the output variance. We discuss applications to time series forecasting, statistical process control, and automatic feedback control of industrial processes. © 2010 Wiley Periodicals, Inc. Naval Research Logistics, 2010     

Clinical Characterization of Insomnia among Veterans with PTSD: Identifying Risk Factors for Diagnosis and Treatment with Sedative-Hypnotics

Abstract

Insomnia is prevalent among Veterans with post-traumatic stress disorder (PTSD), it exacerbates PTSD symptoms, and it contributes to impaired functioning and quality of life. To improve treatment outcomes, it is important to identify risk factors for insomnia and sedative-hypnotic use. Classification and regression trees and logistic regression models were used to identify variables associated with insomnia or sedative-hypnotic use. Key findings include low insomnia diagnosis rates (3.5–5.6%) and high rates of sedative-hypnotics (44.2–49.0%). Younger Veterans and those without a breathing-related sleep disorder (BRSD) were more likely to receive an insomnia diagnosis. Veterans with greater service connection and those with an alcohol/substance use disorder were more likely to be prescribed sedative-hypnotics. Interaction terms may have identified potential groups at risk of being under-diagnosed with insomnia (i.e. non-black Veterans with psychiatric co-morbidity, black Veterans without psychiatric co-morbidity) as well as groups at risk for sedative-hypnotic use (i.e. younger Veterans without BRSD). In sum, Veterans with PTSD have high rates of sedative-hypnotic use despite minimal evidence they are effective. This is counter to recommendations indicating behavioral interventions are the first-line treatment. Policy changes are needed to reduce use of sedative-hypnotics and increase access to behavioral insomnia interventions.     

An experimental comparison of solution algorithms for the single-machine tardiness problem

A basic problem in scheduling involves the sequencing of a set of independent tasks at a single facility with the objective of minimizing mean tardiness. Although the problem is relatively simple, the determination of an optimal sequence remains a challenging combinatorial problem. A number of algorithms have been developed for finding solutions, and this paper reports a comparative evaluation of these procedures. Computer programs for five separate algorithms were written and all were run on a data base designed to highlight computational differences. Optimizing algorithms developed by Emmons and by Srinivasan appeared to be particularly efficient in the comparative study.     

Properties of an approximate hazard transform

The calculation of the exact reliability of complex systems is a difficult and tedious task. Consequently simple approximating techniques have great practical value. The hazard transform of a system is an invertible transformation of its reliability function which is convenient and useful in both applied and theoretical reliability work. A simple calculus for finding an approximate hazard transform for systems formed by series and parallel combinations of components is extended so that it can be used for any coherent system. The extended calculus is shown to lead to conservative approximations. A first order version of the extended calculus is also discussed. This method of approximation is even more simple to use, but is not always conservative. Examples of its application indicate that it is capable of giving quite accurate results.