A stochastic programming approach for chemotherapy appointment scheduling

Chemotherapy appointment scheduling is a challenging problem due to the uncertainty in premedication and infusion durations. In this paper, we formulate a two‐stage stochastic mixed integer programming model for the chemotherapy appointment scheduling problem under limited availability of nurses and infusion chairs. The objective is to minimize the expected weighted sum of nurse overtime, chair idle time, and patient waiting time. The computational burden to solve real‐life instances of this problem to optimality is significantly high, even in the deterministic case. To overcome this burden, we incorporate valid bounds and symmetry breaking constraints. Progressive hedging algorithm is implemented in order to solve the improved formulation heuristically. We enhance the algorithm through a penalty update method, cycle detection and variable fixing mechanisms, and a linear approximation of the objective function. Using numerical experiments based on real data from a major oncology hospital, we compare our solution approach with several scheduling heuristics from the relevant literature, generate managerial insights related to the impact of the number of nurses and chairs on appointment schedules, and estimate the value of stochastic solution to assess the significance of considering uncertainty.     

The stochastic joint replenishment problem: A new policy,analysis, and insights

In this study, we propose a new parsimonious policy for the stochastic joint replenishment problem in a single‐location, N‐item setting. The replenishment decisions are based on both group reorder point‐group order quantity and the time since the last decision epoch. We derive the expressions for the key operating characteristics of the inventory system for both unit and compound Poisson demands. In a comprehensive numerical study, we compare the performance of the proposed policy with that of existing ones over a standard test bed. Our numerical results indicate that the proposed policy dominates the existing ones in 100 of 139 instances with comparably significant savings for unit demands. With batch demands, the savings increase as the stochasticity of demand size gets larger. We also observe that it performs well in environments with low demand diversity across items. The inventory system herein also models a two‐echelon setting with a single item, multiple retailers, and cross docking at the upper echelon. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006     

Approximating the nondominated frontiers of multi‐objective combinatorial optimization problems

Finding all nondominated vectors for multi‐objective combinatorial optimization (MOCO) problems is computationally very hard in general. We approximate the nondominated frontiers of MOCO problems by fitting smooth hypersurfaces. For a given problem, we fit the hypersurface using a single nondominated reference vector. We experiment with different types of MOCO problems and demonstrate that in all cases the fitted hypersurfaces approximate all nondominated vectors well. We discuss that such an approximation is useful to find the neighborhood of preferred regions of the nondominated vectors with very little computational effort. Further computational effort can then be spent in the identified region to find the actual nondominated vectors the decision maker will prefer. © 2009 Wiley Periodicals, Inc. Naval Research Logistics, 2009