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State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.  相似文献   
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The Federal Aviation Administration (FAA) and the airline community within the United States have adopted a new paradigm for air traffic flow management, called Collaborative Decision Making (CDM). A principal goal of CDM is shared decision‐making responsibility between the FAA and airlines, so as to increase airline control over decisions that involve economic tradeoffs. So far, CDM has primarily led to enhancements in the implementation of Ground Delay Programs, by changing procedures for allocating slots to airlines and exchanging slots between airlines. In this paper, we discuss how these procedures may be formalized through appropriately defined optimization models. In addition, we describe how inter‐airline slot exchanges may be viewed as a bartering process, in which each “round” of bartering requires the solution of an optimization problem. We compare the resulting optimization problem with the current procedure for exchanging slots and discuss possibilities for increased decision‐making capabilities by the airlines. © 2005 Wiley Periodicals, Inc. Naval Research Logistics, 2006  相似文献   
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本文从公平与效率视角对新疆少数民族普通高等教育发展进行了分析,指出了新疆少数民族普通高等教育发展中存在的公平与效率问题,为了新疆少数民族高等教育的健康持续发展,对新疆少数民族高等教育发展中存在的效率与公平问题提出了一些建议。  相似文献   
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少数民族教育是我国教育的重要组成部分。发展少数民族教育,提高民族素质具有重要意义。本文从经济学中的效率与公平、供给与需求、成本与效益三个方面理论来分析我国的少数民族教育,从而更好地发展少数民族教育。  相似文献   
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An equity model between groups of demand points is proposed. The set of demand points is divided into two or more groups. For example, rich and poor neighborhoods and urban and rural neighborhoods. We wish to provide equal service to the different groups by minimizing the deviation from equality among groups. The distance to the closest facility is a measure of the quality of service. Once the facilities are located, each demand point has a service distance. The objective function, to be minimized, is the sum of squares of differences between all pairs of service distances between demand points in different groups. The problem is analyzed and solution techniques are proposed for the location of a single facility in the plane. Computational experiments for problems with up to 10,000 demand points and rectilinear, Euclidean, or general ?p distances illustrate the efficiency of the proposed algorithm. © 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011  相似文献   
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效率是社会经济发展的重要保证,而公平是衡量人类文明的重要尺度,是维护社会稳定的价值基础。效率与公平是辩证的对立统一,既有矛盾性又有统一性。公共政策的关键就是要协调与整合二者之间的关系,确保既能提高经济效率,又能实现社会公平——借助市场机制达到资源的有效配置,以提高效率;依靠社会主义制度解决财富分配不公,以彰显公平。将效率与公平完美地结合于公共政策之中,是社会主义优越性的充分体现。  相似文献   
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