Equity in genetic newborn screening

State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.     

考虑腐蚀因素的船体结构寿命预测方法

为建立考虑腐蚀因素的船体结构寿命预测方法,在分析现有常用的船体结构腐蚀损伤时变模型的基础上,根据舰船维修保障实际情况建立了考虑腐蚀防护系统作用时间和维修时间等因素的腐蚀时变模型。根据相关规范选择了船体结构腐蚀寿命标准,并建立了一种计算船体结构腐蚀寿命的方法。该方法建立了船体结构腐蚀寿命与腐蚀防护系统作用时间和修理时间等因素之间的量化关系,可以用于预测均匀腐蚀条件下船体结构寿命,也可以反过来指导腐蚀防护系统设计指标的选择和船体结构维修策略的确定。     

Storage life prediction under pre-strained thermally-accelerated aging of HTPB coating using the change of crosslinking density

In order to predict the storage life of a certain type of HTPB (hydroyl-terminated polybutadiene) coating at 25 C and analyze the influence of pre-strain on the storage life, the accelerated aging tests of HTPB coating at 40 C, 50 C, 60 C, 70 C with the pre-strain of 0%, 3%, 6%, 9%, respectively were carried out. The variation regularity of the change of crosslinking density was analyzed and the aging model of HTPB coating under pre-strained thermally-accelerated aging was proposed. The storage life of HTPB coating at 25 C was estimated by using the Berthelot equation as the end point of the aging life with a 30% decrease in maximum elongation. The results showed that the change of crosslinking density of HTPB coating increased with the increase of aging temperature and aging time, and decreased with the in-crease of pre-strain. Under 0% pre-strain, the relationship between the change of crosslinking density of HTPB coating and the aging time can be described by the logarithmic model with the confidence probability greater than 99%.The stress relaxation phenomenon existed under 3%, 6% and 9% pre-strained aging. The aging model considering chemical aging and pre-strain was established with the confidence probability greater than 90%. The storage life of HTPB coating was 15.2935 years at 25 C under 0% pre-strain, which was reduced by 13.9007%, 75.6949% and 89.7859% under 3%, 6% and 9% pre-strain, respectively. The existence of pre-strain has a serious impact on the storage life of HTPB coating, therefore, the pre-strain should be avoided as much as possible during the actual storage.     

卫星地面站自动测试软件的“三化”设计

应用MVC设计模式,采用PIM应用架构,通过动态链接库和构件技术,对卫星地面站自动测试软件进行了通用化、系列化和组合化设计。     

舰空导弹武器系统软件靶场综合测试分析

针对舰空导弹武器系统的特点以及舰空导弹武器系统软件定型试验的现状,指出了舰空导弹武器系统软件靶场测试的必要性、特殊性。通过靶场软件测试综合试验,总结了舰空导弹武器系统软件靶场定型的试验方法。并指出了靶场软件测试的发展方向。     

从艺术客体的选择看中国古代戏剧家表现社会生活内容的广阔性

中国古代戏剧家在戏剧人物艺术客体的选择上,同古希腊悲喜剧和印度梵剧迥然不同,表现出别具一格的建树和开拓性,初步形成了具有中国作风和中国气派的戏剧文化,并在这种戏剧文化中体现了中国古代剧作家们主体精神的独立不羁的自由品格和表现社会生活内容的无限广阔性。     

A stochastic model for burn‐in procedures in accelerated environment

Burn‐in procedure is a manufacturing technique that is intended to eliminate early failures of system or product. Burning‐in a component or system means to subject it to a period of use prior to being used in field. Generally, burn‐in is considered expensive and so the length of burn‐in is typically limited. Thus, burn‐in is most often accomplished in an accelerated environment in order to shorten the burn‐in process. A new failure rate model for an accelerated burn‐in procedure, which incorporates the accelerated ageing process induced by the accelerated environmental stress, is proposed. Under a more general assumption on the shape of failure rate function of products, which includes the traditional bathtub‐shaped failure rate function as a special case, upper bounds for optimal burn‐in time will be derived. A numerical example will also be given for illustration. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006     

爆炸复合接头剪切强度测试方法研究

参照正交各向异性层压复合板层间剪切强度的测试方法,提出了用于测试爆炸复合接头复合界面剪切强度的3种方法;并建立三维有限元模型,分别对3种测试方法进行模拟;最后分别对3种方法进行了测试试验.结果表明,3种试验方法均能有效测试爆炸复合接头的剪切强度,其中对称试件双切口拉伸法最适合实际应用.     

基于退化速率跟踪粒子滤波的剩余使用寿命预测框架

毋庸置疑,剩余使用寿命预测对于设备的健康管理越来越重要。近年来粒子滤波方法被越来越多地应用到设备寿命预测技术当中,这是因为粒子滤波方法能更好的解决非线性非高斯系统滤波问题,而且能够获得不确定度信息。但该方法的预测性能却过度依赖于预测模型,并且对于模型参数的初始分布也比较敏感,这在一定程度上限制了粒子滤波预测方法的进一步发展。本文针对基本粒子滤波预测方法的不足,提出了一种基于退化速率跟踪粒子滤波的通用预测框架,以历史观测数据的退化速率统计规律作为指导来跟踪目标数据的退化速率,实现对粒子滤波预测方法的简化。并将该方法用于轴承和锂离子电池的剩余使用寿命预测,验证了方法的有效性。     

基于EMD的改进小波阈值降噪法在超声信号处理中的应用

针对超声检测回波信号中的大量噪声,分析了超声检测回波信号的特性,考虑经验模式分解（EMD）和小波哗噪的优点,在改进阈值函数基础上提出一种基于EMD的小波阈值降噪方法．该方法利用EMD对超声信号进行分解,对高频分量用改进小波阈值函数方法进行处理,再结合低频分量重构得到降噪信号．仿真实验结果表明,该方法降噪效果优于小波软、硬阂值降噪,进一步提高了重建信号的信噪比,降低了其均方根误差,是一种可行的超声信号降噪方法．