Equity in genetic newborn screening

State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.     

基于响应面法的悬架系统优化研究

提出了应用响应面分析履带车辆悬架系统特性的方法。构建了悬架系统特性参数和整车行驶平顺性及可靠性之间的二阶响应面模型,并依据响应面分析结果,进行悬架系统的优化研究。优化结果表明了该方法的有效性。     

新型装甲装备部队试用初探

新装备不经部队试用就批量生产交付部队使用,是导致新装备质量水平低、长期不能形成保障能力的重要原因之一。开展部队试用是提高新装备的质量与可靠性水平,促进新装备尽快形成作战、保障能力的重要途径之一。分析了开展新装备部队试用工作的必要性,探讨了新型装甲装备部队试用的基本任务,并对如何开展装甲新装备部队试用工作提出了几点建议。     

基于可信度的网络安全性分析方法

提出了一个基于可信度方法的网络安全性分析模型。该模型在脆弱点信息、脆弱点之间的关系、脆弱点与安全性的关系的表示中引入可信度因子,通过不确定推理对主机和网络的安全性进行分析。该模型能综合考虑诸多因素,有效处理安全性分析中的不确定知识。     

基于模糊综合评判的装备软件可靠性分析

可靠性是衡量装备软件质量的重要参数,但由于软件可靠性的特点,在实际对装备软件可靠性定量分析往往很难,甚至不可能。从软件质量框架模型出发,结合装备软件的特点,分析了影响装备软件可靠性的几个参数,提出了一种运用模糊综合评判方法对装备软件可靠性进行定性分析的方法。该方法简单,可行性强。最后,给出了一个实例。     

卫星地面站自动测试软件的“三化”设计

应用MVC设计模式,采用PIM应用架构,通过动态链接库和构件技术,对卫星地面站自动测试软件进行了通用化、系列化和组合化设计。     

舰空导弹武器系统软件靶场综合测试分析

针对舰空导弹武器系统的特点以及舰空导弹武器系统软件定型试验的现状,指出了舰空导弹武器系统软件靶场测试的必要性、特殊性。通过靶场软件测试综合试验,总结了舰空导弹武器系统软件靶场定型的试验方法。并指出了靶场软件测试的发展方向。     

A stochastic model for burn‐in procedures in accelerated environment

Burn‐in procedure is a manufacturing technique that is intended to eliminate early failures of system or product. Burning‐in a component or system means to subject it to a period of use prior to being used in field. Generally, burn‐in is considered expensive and so the length of burn‐in is typically limited. Thus, burn‐in is most often accomplished in an accelerated environment in order to shorten the burn‐in process. A new failure rate model for an accelerated burn‐in procedure, which incorporates the accelerated ageing process induced by the accelerated environmental stress, is proposed. Under a more general assumption on the shape of failure rate function of products, which includes the traditional bathtub‐shaped failure rate function as a special case, upper bounds for optimal burn‐in time will be derived. A numerical example will also be given for illustration. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006     

Transient analysis of Markov models of fault‐tolerant systems with deferred repair using split regenerative randomization

The (standard) randomization method is an attractive alternative for the transient analysis of continuous time Markov models. The main advantages of the method are numerical stability, well‐controlled computation error, and ability to specify the computation error in advance. However, the fact that the method can be computationally very expensive limits its applicability. In this paper, we develop a new method called split regenerative randomization, which, having the same good properties as standard randomization, can be significantly more efficient. The method covers reliability‐like models with a particular but quite general structure and requires the selection of a subset of states and a regenerative state satisfying some conditions. For a class of continuous time Markov models, model class C₂, including typical failure/repair reliability‐like models with exponential failure and repair time distributions and deferred repair, natural selections are available for both the subset of states and the regenerative state and, for those natural selections, theoretical results are available assessing the efficiency of the method in terms of “visible” model characteristics. Those results can be used to anticipate when the method can be expected to be competitive. We illustrate the application of the method using a large class C₂ model and show that for models in that class the method can indeed be significantly more efficient than previously available randomization‐based methods. © 2006 Wiley Periodicals, Inc. Naval Research Logistics, 2006     

爆炸复合接头剪切强度测试方法研究

参照正交各向异性层压复合板层间剪切强度的测试方法,提出了用于测试爆炸复合接头复合界面剪切强度的3种方法;并建立三维有限元模型,分别对3种测试方法进行模拟;最后分别对3种方法进行了测试试验.结果表明,3种试验方法均能有效测试爆炸复合接头的剪切强度,其中对称试件双切口拉伸法最适合实际应用.