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In 2007, 334 nuclear reactors (including for naval propulsion) and isotope production facilities employed highly enriched uranium (HEU) fuel or target material. One year of operations at these reactors and facilities required more than 3,100 kilograms (kg) of HEU for naval propulsion, more than 750 kg for research reactors, and 40?–50 kg for isotope production in civilian facilities—in addition to several tons used in other types of reactors. Material with high enrichment levels and low radiation barriers stored or handled in large batches, such as HEU target waste and certain types of fuel from isotope production, research reactors/critical assemblies, and naval fuel, presents serious safety and security concerns. Forty-eight civilian research reactors have converted to low-enriched uranium as a result of a three-decade international effort to minimize HEU use, resulting in a decrease in HEU consumption of 278 kg per year. This article's establishment of baseline measurements for assessing the results of HEU minimization efforts calls for additional focus on the scope and methodology of HEU minimization. Facility decommissioning and dismantling should play a larger role in the future HEU minimization effort, materials with specific weapons-relevant properties should be given higher priority compared to bulk HEU material, and the use of large quantities of weapon-grade HEU fuel for naval propulsion should be reconsidered.  相似文献   
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